Insulin resistance and glycine metabolism in humans - PubMed

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A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes.

Halama A, Zaghlool S, Thareja G, Kader S, Al Muftah W, Mook-Kanamori M, Sarwath H, Mohamoud YA, Stephan N, Ameling S, Pucic Baković M, Krumsiek J, Prehn C, Adamski J, Schwenk JM, Friedrich N, Völker U, Wuhrer M, Lauc G, Najafi-Shoushtari SH, Malek JA, Graumann J, Mook-Kanamori D, Schmidt F, Suhre K. Halama A, et al. Nat Commun. 2024 Aug 19;15(1):7111. doi: 10.1038/s41467-024-51134-x. Nat Commun. 2024. PMID: 39160153 Free PMC article.

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https://pubmed.ncbi.nlm.nih.gov/29094215/#:~:text=Plasma%20glycine%20level%20is%20low%20in%20patients%20with,with%20decreased%20risk%20of%20incident%20type%202%20diabetes.

Tóm tắt

这篇文章探讨了将多组学数据与人群特征和糖尿病亚型相结合的分子人类学路线图。研究者们强调了多组学在理解复杂疾病（如糖尿病）中的重要性，提出了一种整合基因组学、转录组学、蛋白质组学和代谢组学的方法，以揭示不同人群中糖尿病的生物标志物和潜在机制。文章还讨论了如何利用这些数据来识别糖尿病的亚型，从而为个性化医疗提供支持。通过这种多维度的分析，研究旨在推动对糖尿病及其相关疾病的理解，最终改善预防和治疗策略。