Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

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Page 2

Mitochondrial viscosity

Myocardial I/R injury

Viscosity influences protein-protein interactions in mitochondrial membranes and is associated with various diseases. Mitochondrial viscosity increases during ferroptosis. The fluorescence probe PPAC-C4 is used for ultra-precision quantification of mitochondrial viscosity by attaching mitochondrial-targeting cation fragments to a vibration-based fluorescent scaffold. The probe Mito-3, containing a cationic quinoline unit and a C12 chain, can be used to locate and monitor changes in intracellular mitochondrial viscosity at close range by near infrared fluorescence.

The probe CBS, based on the docking of electrostatic force and prop-protein molecules, achieves stable and accurate detection of mitochondrial viscosity.

997,998,999

Link
https://www.nature.com/articles/s41392-024-01969-z
Resumir
这篇文章综述了铁死亡（ferroptosis）的最新研究进展，回顾了其机制、生理功能及治疗应用。铁死亡是一种新型的细胞死亡方式，涉及铁离子和脂质过氧化物的积累。文章指出，铁死亡在多种疾病中扮演重要角色，包括癌症、神经退行性疾病和心血管疾病。研究者们探讨了铁死亡的信号通路及其与细胞代谢的关系，强调了其在疾病治疗中的潜力。此外，文章还讨论了铁死亡的检测方法及其在临床应用中的前景。通过对铁死亡的深入理解，未来可能开发出新的治疗策略，以改善相关疾病的预后。