Skin chronological aging drives age-related bone loss via secretion of cystatin-A

contenu
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Lien
https://www.nature.com/articles/s43587-022-00285-x
Résumer
本文综述了骨质疏松症与皮肤老化之间的关系，强调了骨髓、细胞因子及骨重塑在骨质疏松病理生理中的重要性。研究表明，骨质疏松症与皮肤胶原蛋白的流失密切相关，且这种流失是可逆的。多项研究探讨了不同因素对成骨细胞和破骨细胞分化的独立影响，以及皮肤和骨骼在衰老过程中的萎缩关系。此外，皮肤厚度减少与骨密度降低之间的风险因素也被提出，提示可能的病理生理机制、预防和治疗方法。最新的观察性研究显示，皮肤脆弱症与重大骨质疏松性骨折历史之间存在关联，进一步支持了皮肤和骨骼健康之间的联系。总之，骨质疏松症和皮肤老化的研究为理解衰老过程提供了新的视角，并为未来的治疗策略奠定了基础。