Ironing out the details of ferroptosis

contenu
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Lien
https://www.nature.com/articles/s41556-024-01361-7?fromPaywallRec=false
Résumer
本文综述了真核生物铁代谢的化学和生物学，探讨了铁在细胞中的重要性及其代谢调控机制。研究表明，铁不仅是细胞生长和代谢所必需的元素，还与多种生理过程密切相关，如氧气运输和DNA合成。文章回顾了铁的吸收、储存和运输机制，以及与铁相关的疾病，如慢性病贫血和铁代谢障碍。作者强调了铁硫蛋白在铁代谢中的关键作用，并讨论了其生物合成和功能的新见解。此外，文中提到的多篇文献为理解铁代谢的分子机制提供了重要的实验数据和理论支持。整体而言，本文为研究铁代谢的生物学基础和临床应用提供了全面的视角。