1. Gupta M, Mazumder UK, Gomathi P, Selvan VT. Antiinflammatory evaluation of leaves of Plumeria acuminata. BMC Complement Altern Med. 2006;6:36. [PMC free article] [PubMed] [Google Scholar]
2. Nigam V, Sodhi JS. Some medicinal plants with antioxidant activity – A review. Int J Pharm Biol Sci. 2014;4:173–8. [Google Scholar]
3. Gupta VK, Sharma SK. Plants as natural antioxidants. Nat Prod Radiance. 2006;5:326–34. [Google Scholar]
4. Salvamani S, Gunasekaran B, Shaharuddin NA, Ahmad SA, Shukor MY. Antiartherosclerotic effects of plant flavonoids. Biomed Res Int 2014. 2014:480258. [PMC free article] [PubMed] [Google Scholar]
5. Sultana B, Anwar F. Flavonols (Kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants. Food Chem. 2008;108:879–84. [PubMed] [Google Scholar]
6. Parasuraman S, Maithili KS. Antioxidant and drug metabolism. Free Radic Antioxid. 2014;4:1–2. [Google Scholar]
7. Pham-Huy LA, He H, Pham-Huy C. Free radicals, antioxidants in disease and health. Int J Biomed Sci. 2008;4:89–96. [PMC free article] [PubMed] [Google Scholar]
8. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44–84. [PubMed] [Google Scholar]
9. Blokhina O, Virolainen E, Fagerstedt KV. Antioxidants, oxidative damage and oxygen deprivation stress: A review. Ann Bot. 2003;91:179–94. [PMC free article] [PubMed] [Google Scholar]
10. Sandhar HK, Kumar B, Prasher S, Tiwari P, Salhan M, Sharma P. A review of phytochemistry and pharmacology of flavonoids. Int Pharm Sci. 2011;1:25–41. [Google Scholar]
11. Agrawal AD. Pharmacological activities of flavonoids: Review. Int J Pharm Nanotechnol. 2011;4:1394–7. [Google Scholar]
12. Pal DK, Verma P. Flavonoids: A powerful and abundant source of antioxidants. Int J Pharm Pharm Sci. 2013;5:95–8. [Google Scholar]
13. Procházková D, Boušová I, Wilhelmová N. Antioxidant and prooxidant properties of flavonoids. Fitoterapia. 2011;82:513–23. [PubMed] [Google Scholar]
14. Lakhanpal P, Rai DK. Quercetin: A versatile flavonoid. Int J Med Update. 2007;2:22–37. [Google Scholar]
15. Begum AN, Terao J. Protective effect of quercetin against cigarette tar extract-induced impairment of erythrocyte deformability. J Nutr Biochem. 2002;13:265–72. [PubMed] [Google Scholar]
16. Xiao X, Shi D, Liu L, Wang J, Xie X, Kang T, et al. Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling. PLoS One. 2011;6(8):e22934. [PMC free article] [PubMed] [Google Scholar]
17. Warren CA, Paulhill KJ, Davidson LA, Lupton JR, Taddeo SS, Hong MY, et al. Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. J Nutr. 2009;139:101–5. [PMC free article] [PubMed] [Google Scholar]
18. Chun OK, Chung SJ, Claycombe KJ, Song WO. Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults. J Nutr. 2008;138:753–60. [PubMed] [Google Scholar]
19. García-Mediavilla V, Crespo I, Collado PS, Esteller A, Sánchez-Campos S, Tuñón MJ, et al. The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol. 2007;557:221–9. [PubMed] [Google Scholar]
20. Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco. 2001;56:683–7. [PubMed] [Google Scholar]
21. Mamani-Matsuda M, Kauss T, Al-Kharrat A, Rambert J, Fawaz F, Thiolat D, et al. Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators. Biochem Pharmacol. 2006;72:1304–10. [PubMed] [Google Scholar]
22. Askari G, Ghiasvand R, Feizi A, Ghanadian SM, Karimian J. The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. J Res Med Sci. 2012;17:637–41. [PMC free article] [PubMed] [Google Scholar]
23. Javadi F, Eghtesadi S, Ahmadzadeh A, Aryaeian N, Zabihiyeganeh M, Foroushani AR, et al. The effect of quercetin on plasma oxidative status, C-reactive protein and blood pressure in women with rheumatoid arthritis. Int J Prev Med. 2014;5:293–301. [PMC free article] [PubMed] [Google Scholar]
24. Ahmad NS, Farman M, Najmi MH, Mian KB, Hasan A. Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout. J Ethnopharmacol. 2008;117:478–82. [PubMed] [Google Scholar]
25. Parasuraman S, Kumar E, Kumar A, Emerson S. Free radical scavenging property and diuretic effect of triglize, a polyherbal formulation in experimental models. J Pharmacol Pharmacother. 2010;1:38–41. [PMC free article] [PubMed] [Google Scholar]
26. Dauchet L, Amouyel P, Dallongeville J. Fruit and vegetable consumption and risk of stroke: A meta-analysis of cohort studies. Neurology. 2005;65:1193–7. [PubMed] [Google Scholar]
27. He FJ, Nowson CA, MacGregor GA. Fruit and vegetable consumption and stroke: Meta-analysis of cohort studies. Lancet. 2006;367:320–6. [PubMed] [Google Scholar]
28. Lekakis J, Rallidis LS, Andreadou I, Vamvakou G, Kazantzoglou G, Magiatis P, et al. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil. 2005;12:596–600. [PubMed] [Google Scholar]
29. Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. 2007;137:2405–11. [PubMed] [Google Scholar]
30. Chopra M, Fitzsimons PE, Strain JJ, Thurnham DI, Howard AN. Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations. Clin Chem. 2000;46(8 Pt 1):1162–70. [PubMed] [Google Scholar]
31. Egert S, Bosy-Westphal A, Seiberl J, Kürbitz C, Settler U, Plachta-Danielzik S, et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: A double-blinded, placebo-controlled cross-over study. Br J Nutr. 2009;102:1065–74. [PubMed] [Google Scholar]
32. Ahn J, Lee H, Kim S, Park J, Ha T. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem Biophys Res Commun. 2008;373:545–9. [PubMed] [Google Scholar]
33. Park HJ, Yang JY, Ambati S, Della-Fera MA, Hausman DB, Rayalam S, et al. Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes. J Med Food. 2008;11:773–83. [PubMed] [Google Scholar]
34. Strobel P, Allard C, Perez-Acle T, Calderon R, Aldunate R, Leighton F. Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. Biochem J. 2005;386(Pt 3):471–8. [PMC free article] [PubMed] [Google Scholar]
35. Yang JY, Della-Fera MA, Rayalam S, Ambati S, Hartzell DL, Park HJ, et al. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci. 2008;82:1032–9. [PubMed] [Google Scholar]
36. Pereira MA, O'Reilly E, Augustsson K, Fraser GE, Goldbourt U, Heitmann BL, et al. Dietary fiber and risk of coronary heart disease: A pooled analysis of cohort studies. Arch Intern Med. 2004;164:370–6. [PubMed] [Google Scholar]
37. Huxley RR, Neil HA. The relation between dietary flavonol intake and coronary heart disease mortality: A meta-analysis of prospective cohort studies. Eur J Clin Nutr. 2003;57:904–8. [PubMed] [Google Scholar]
38. Choi GN, Kim JH, Kwak JH, Jeong CH, Jeong HR, Lee U, et al. Effect of quercetin on learning and memory performance in ICR mice under neurotoxic trimethyltin exposure. Food Chem. 2012;132:1019–24. [Google Scholar]
39. Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP. The neuroprotective potential of flavonoids: A multiplicity of effects. Genes Nutr. 2008;3:115–26. [PMC free article] [PubMed] [Google Scholar]
40. Youdim KA, Joseph JA. A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: A multiplicity of effects. Free Radic Biol Med. 2001;30:583–94. [PubMed] [Google Scholar]
41. Lamson DW, Brignall MS. Antioxidants and cancer, part 3: Quercetin. Altern Med Rev. 2000;5:196–208. [PubMed] [Google Scholar]
42. Akan Z, Garip AI. Antioxidants may protect cancer cells from apoptosis signals and enhance cell viability. Asian Pac J Cancer Prev. 2013;14:4611–4. [PubMed] [Google Scholar]
43. Vásquez-Garzón VR, Arellanes-Robledo J, García-Román R, Aparicio-Rautista DI, Villa-Treviño S. Inhibition of reactive oxygen species and pre-neoplastic lesions by quercetin through an antioxidant defense mechanism. Free Radic Res. 2009;43:128–37. [PubMed] [Google Scholar]
44. Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, Wexner SD, et al. Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol. 2006;4:1035–8. [PubMed] [Google Scholar]
45. Pratheeshkumar P, Son YO, Divya SP, Wang L, Turcios L, Roy RV, et al. Quercetin inhibits Cr (VI)-induced malignant cell transformation by targeting miR-21-PDCD4 signaling pathway. Oncotarget. 2016 Ahead of print. [PMC free article] [PubMed] [Google Scholar]
46. Han M, Song Y, Zhang X. Quercetin suppresses the migration and invasion in human colon cancer caco-2 cells through regulating toll-like receptor 4/nuclear factor-kappa B pathway. Pharmacogn Mag. 2016;12(Suppl 2):S237–44. [PMC free article] [PubMed] [Google Scholar]
47. Yang F, Song L, Wang H, Wang J, Xu Z, Xing N. Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (Review) Oncol Rep. 2015;33:2659–68. [PubMed] [Google Scholar]
48. Suzuki Y, Ishihara M, Segami T, Ito M. Anti-ulcer effects of antioxidants, quercetin, alpha-tocopherol, nifedipine and tetracycline in rats. Jpn J Pharmacol. 1998;78:435–41. [PubMed] [Google Scholar]
49. Alarcón de la Lastra C, Martín MJ, Motilva V. Antiulcer and gastroprotective effects of quercetin: A gross and histologic study. Pharmacology. 1994;48:56–62. [PubMed] [Google Scholar]
50. Johari J, Kianmehr A, Mustafa MR, Abubakar S, Zandi K. Antiviral activity of baicalein and quercetin against the Japanese encephalitis virus. Int J Mol Sci. 2012;13:16785–95. [PMC free article] [PubMed] [Google Scholar]
51. Cushnie TP, Lamb AJ. Antimicrobial activity of flavonoids. Int J Antimicrob Agents. 2005;26:343–56. [PMC free article] [PubMed] [Google Scholar]
52. Ramos FA, Takaishi Y, Shirotori M, Kawaguchi Y, Tsuchiya K, Shibata H, et al. Antibacterial and antioxidant activities of quercetin oxidation products from yellow onion (Allium cepa) skin. J Agric Food Chem. 2006;54:3551–7. [PubMed] [Google Scholar]
53. Coles LS. Quercetin: A Review of Clinical Applications. [Last accessed on 2016 Jul 06]. Available from: http://www.chiro.org/nutrition/ABSTRACTS/Quercetin_A_Review.shtml .
54. Ferry DR, Smith A, Malkhandi J, Fyfe DW, deTakats PG, Anderson D, et al. Phase I clinical trial of the flavonoid quercetin: Pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin Cancer Res. 1996;2:59–68. [PubMed] [Google Scholar]
55. Erlund I, Kosonen T, Alfthan G, Mäenpää J, Perttunen K, Kenraali J, et al. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharmacol. 2000;56:545–53. [PubMed] [Google Scholar]
56. Graefe EU, Wittig J, Mueller S, Riethling AK, Uehleke B, Drewelow B, et al. Pharmacokinetics and bioavailability of quercetin glycosides in humans. J Clin Pharmacol. 2001;41:492–9. [PubMed] [Google Scholar]
57. Heinz SA, Henson DA, Austin MD, Jin F, Nieman DC. Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial. Pharmacol Res. 2010;62:237–42. [PMC free article] [PubMed] [Google Scholar]
58. Denny Joseph KM, Muralidhara Enhanced neuroprotective effect of fish oil in combination with quercetin against 3-nitropropionic acid induced oxidative stress in rat brain. Prog Neuropsychopharmacol Biol Psychiatry. 2013;40:83–92. [PubMed] [Google Scholar]
59. Egert S, Boesch-Saadatmandi C, Wolffram S, Rimbach G, Müller MJ. Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. J Nutr. 2010;140:278–84. [PubMed] [Google Scholar]
60. Brüll V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, Müller C, et al. Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-) hypertension: A randomised double-blinded placebo-controlled cross-over trial. Br J Nutr. 2015;114:1263–77. [PMC free article] [PubMed] [Google Scholar]
61. Zahedi M, Ghiasvand R, Feizi A, Asgari G, Darvish L. Does quercetin improve cardiovascular risk factors and inflammatory biomarkers in women with type 2 diabetes: A Double-blind Randomized Controlled Clinical Trial. Int J Prev Med. 2013;4:777–85. [PMC free article] [PubMed] [Google Scholar]
62. Shoskes D, Lapierre C, Cruz-Correa M, Muruve N, Rosario R, Fromkin B, et al. Beneficial effects of the bioflavonoids curcumin and quercetin on early function in cadaveric renal transplantation: A randomized placebo controlled trial. Transplantation. 2005;80:1556–9. [PubMed] [Google Scholar]
63. Amirchaghmaghi M, Delavarian Z, Iranshahi M, Shakeri MT, Mosannen Mozafari P, Mohammadpour AH, et al. A Randomized placebo-controlled double blind clinical trial of quercetin for treatment of oral lichen planus. J Dent Res Dent Clin Dent Prospects. 2015;9:23–8. [PMC free article] [PubMed] [Google Scholar]
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