Vertebrate food products as a potential source of prion-like α-synuclein

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Link
https://www.nature.com/articles/s41531-017-0035-z
Summary
The articles listed provide a comprehensive overview of Parkinson's disease (PD), focusing on its symptoms, treatments, and underlying mechanisms. Vidailhet (2011) discusses the clinical manifestations and therapeutic approaches for PD, while Goldman and Postuma (2014) explore premotor and nonmotor features that can precede the diagnosis. The neuropathological aspects are examined by Paulus and Jellinger (1991), who categorize clinical subgroups based on distinct pathological findings. Gibb and Lees (1991) delve into the anatomy and differential cell death in the substantia nigra, a critical area affected in PD. Pankratz et al. (2009) conduct a genome-wide association study to identify genetic factors contributing to familial PD. Stefanis (2012) highlights the role of alpha-synuclein, a protein implicated in PD pathology, while Uversky and Eliezer (2009) discuss its biophysical properties and aggregation. Lavedan (1998) provides insights into the synuclein family, which includes alpha-synuclein. Collectively, these studies enhance our understanding of PD's complexity, from genetic predispositions to clinical manifestations and potential therapeutic targets.